Celiac Disease and Gastrointestinal Functional Disorders

Santos Santolaria Piedrafita


Celiac disease (CD) is one of the most frequent genetic disorders diagnosed in the adult population and it may present a wide spectrum of gastrointestinal symptoms, which bear a large degree of overlap with functional dyspepsia, irritable bowel syndrome (IBS) or functional diarrhea. It has been demonstrated that CD, as diagnosed by positive serology and villous atrophy, is more frequent in patients with functional dyspepsia (1.2-6.2%) and IBS (4.7-11.4%) than in the general population. This prevalence may be higher if we consider the whole spectrum of gluten-dependent mucosal histopathological lesions, including lymphocytic enteropathy. Consequently, patients with these gastrointestinal symptoms might be misdiagnosed with a functional bowel disorder if the diagnostic approach does not include CD-specific antibody tests and duodenal biopsies. This fact might bring, as a result, a delay in CD diagnosis and treatment, with important consequences in terms of morbidity and quality of life. Non-celiac gluten sensitivity is a clinical condition characterized by symptoms that improve after gluten withdrawal, negative celiac serology and absence of enteropathy, which may be involved as a trigger in some functional bowel disorders such as IBS.

Palabras clave

celiac, gastrointestinal

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