Small Intestine Biopsy and its Interpretation: Preliminary Results in Costa Rica

Fernando Brenes, Adelita Herrera


Celiac disease is an autoimmune disease with diverse histopathological changes of the small intestine which are fundamental for the diagnosis of the disease. The main changes are intraepithelial lymphocytic infiltration of the intestinal mucosa, with or without villous atrophy. The number of biopsies has to be adequate, at least six, because the histopathological abnormalities often have a patchy distribution. The disease may exhibit only minimal alterations along with the intraepithelial lymphocytic infiltrate, which can be shared with other non-celiac entities. We recommend the use of the Corazza-Villanacci classification because it has demonstrated a better correlation among pathologists.

We present the results of 258 patients (108 male and 150 female) with celiac disease in Costa Rica with lymphocytic duodenitis and villous atrophy. Mean age was 48.3 years, ranging between 16 and 90 years. Furthermore, in 35 patients, HLA-DQ2 and HLA-DQ8 genotyping was performed; 11 cases were positive for HLA-DQ2, 7 for HLA-DQ8, and 3 for both HLA-DQ2 and HLA-DQ8. 15 cases were negative, but had only lymphocytic duodenitis, which should be studied further and are currently being followed-up.

Palabras clave

celiac, Costa Rica, biopsy, interpretation, small intestine

Texto completo: PDF


  • No hay Refbacks actualmente.

OmniaScience, 2011-2018 -