Celiac Disease and Non-Celiac Gluten Sensitivity

Amado Salvador Peña, Luis Rodrigo


This chapter explains the title of this book and it highlights the importance of recognizing non-celiac gluten sensitivity. It briefly discusses the topics covered in all the chapters within the context of a new definition as well as recent developments in China, Mexico, El Salvador and Costa Rica. The immunological differences between celiac disease and non-celiac gluten sensitivity are reviewed as well as the clinical and pathological differences between celiac disease, gluten allergy, gluten sensitivity and non-celiac gluten intolerance.

The physiological and immunological effects that can be triggered by wheat products are also briefly summarized without mentioning somatization disorders that may apply to some patients with sensitivity or food intolerance. New concepts about placebo and nocebo are described. This new insight suggests the need to include protocols similar to those that can be applied to diets with or without gluten. It is clear that the two opposing mechanisms of placebo and nocebo may come into play not only when administering drugs but also when specific diets are used as treatment. Subsequently, attention is drawn to the chapters on diagnostic techniques such as celiac disease serology, endoscopy and histopathology, as well as those that deal with the various clinical forms of CD in children and adults. Finally, there is a description of the topics relating to celiac disease on which the authors have expertise.

Palabras clave

celiac disease, non-celiac gluten sensitivity

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