Mechanisms of Intestinal Tolerance to Dietary Proteins

David Bernardo, Stella C. Knight


Oral tolerance is defined as the lack of a systemic immune response against antigens previously administered through the gastrointestinal tract. Therefore, in an antigen rich environment such as the intestine, the oral tolerance avoids the development of immune responses against food antigens and the commensal microbiota maintaining immune homeostasis in health. Nevertheless, in some circumstances the immune system fails to develop and/or maintain immune tolerance, triggering an abnormal immune response against the commensals, which occurs in inflammatory bowel diseases and/or against food antigens as evident in coeliac disease. In this chapter, we will discuss the unique properties of the immune system in the gastrointestinal tract and study how dendritic cells, the most potent antigen presenting cells, control mechanisms of immune homeostasis in the intestine.

Palabras clave

dendritic cells, tolerance, intestine, immunity,

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